Mini-mates have done a few of those.
Unless you don't consider mini-mates action figures, which would be fightin' words.
But I wouldn't consider any of them major.
Still, there are gaps in certain teams, that's for sure.
Major as in 20 appearances or more. also add Goblin Queen, Two Gun kid, original Ghost Rider or any westerns.Red Sonja, Hellcat?, 70's GOG, Devil dinosaur, the Eternals, I'm sure I'm forgetting a few.